Helicobacter pylori infection and its risk factors in subjects receiving physical examination

Aim: This study aimed to analyze helicobacter pylori (Hp) risk factors, which may provide evidence for the prevention and treatment of Hp infection. Methods: 8115 subjects were recruited. Questionnaire surgery was done in 487subjects who received gastroscopy. Results: The incidence of Hp infection was 35.2% in males and 30.3% in females showing significant difference (P<0.05). The mean age was 48.65±13.55 years in Hp positive subjects and 45.77±14.10 years in Hp negative subjects, showing marked difference (P<0.05). The body mass index, uric acid, blood glucose, triglycerides and low-density lipoprotein cholesterol in Hp infection subjects were significantly higher than in Hp negative subjects (P<0.05), but the high-density lipoprotein cholesterol in Hp positive subjects was markedly lower than in Hp negative subjects (P<0.05). In 487 subjects, the incidence of Hp infection was 53.6%, which was significantly higher than in healthy subjects (P<0.05). The incidence of Hp infection in subjects living in city, with family members having Hp infection, drinking running water, smoking or drinking alcohol was significantly higher than in controls (P<0.05). The incidence of Hp infection was different between subjects with different gastric diseases (P<0.05). The incidence of Hp infection was the highest in subjects with peptic ulcer and the lowest in those with esophagitis. Conclusion: Hp infection is related to gender, age, body weight, living environments and living habits, which provide evidence for the prevention of Hp infection. Hp infection is closely related to the pathogenesis of diabetes and cardiovascular diseases.